Description
A CB2 receptor inverse agonist; selective for CB2 over CB1 receptors (Kis = 35.9 and 2,370 nM, respectively, for the human receptors); increases forskolin-induced cAMP production in CHO cells expressing human or mouse CB2 receptors; promotes the differentiation of isolated mouse splenic CD4+ T cells into Tregs at 100 nM; decreases disease severity in a mouse model of DNBS-induced IBD; inhibits spontaneous scratching in a mouse model of chronic dermatitis at 1 and 10 mg/kg; reduces carrageenan-induced paw edema in mice (ED50 = 0.05 mg/kg); bilateral injection into the anterior bed nucleus of the stria terminalis decreases the percentage of time spent in the open arms of the elevated plus maze in mice, indicating anxiety-like behavior, at 25 pmol/animal